BTech Biotechnology Syllabus and Subjects - Semester Wise Core & Electives

Duration: 4 Years
Avg Fees: INR 25,000 - 2,50,000 Per Year
Shristi T
Shristi T

Updated on - May 27, 2024

The BTech Biotechnology syllabus deals with the study of topics such as Biochemistry, Environmental Biotechnology, Microbiology, Bioinformatics, Bioprocess Engineering, Molecular Biology, and more. The BTech Biotechnology course curriculum is strategically divided into eight semesters spanning four years.

The syllabus for BTech in Biotechnology may vary depending on the university offering the program. However, the core BTech Biotechnology subjects include Introduction to Biotechnology, Mathematics, Microbiology, Materials Science, Cell Biology, etc, and the elective subjects such as Fermentation Technology, Pharmaceutical Biotechnology, Environmental Engineering, Plant Biotechnology, etc. 

The B.Tech Biotechnology syllabus includes core and elective courses, practicals, internships, and projects that equip students with skills such as laboratory techniques, data analysis, bioprocess design, genetics engineering, etc. B.Tech Biotechnology course aims at preparing students to work in diverse fields such as food, pharmaceuticals, chemicals, bio-products, textiles, medicine, nutrition, etc.

Table of Contents

Semester-Wise BTech Biotechnology Syllabus

The B.Tech Biotechnology in Biotechnology syllabus is divided into 8 semesters in which the first two years have generalized subjects while the next two years have more specialized topics. Listed below is the B.Tech Biotechnology Syllabus semester wise:

B.Tech Biotechnology 1st Year Syllabus

The first-year BTech Biotechnology syllabus focuses on subjects such as Mathematics, Physics, Chemistry, Engineering Mechanics, etc. Listed below is the BTech Biotechnology sem 1 and 2 syllabus:

Semester I

Semester II

Communicative English

Engineering Mathematics-II

Engineering Physics

Material Science

Engineering Chemistry

Civil and Mechanical Engineering

Engineering Mathematics-I

Microbiology

Problem Solving and Python Programming 

Biochemistry

Engineering Graphics 

Environmental Studies

Laboratory/ Practical Work

Laboratory/ Practical Work

Practical Topics for First-Year BTech Biotechnology Syllabus

Listed below are the BTech Biotechnology practical topics for 1st and 2nd semester:

  • Problem-Solving and Python Programming Laboratory
  • Physics and Chemistry Laboratory 
  • Engineering Mechanics Laboratory
  • Biochemistry Laboratory

B.Tech Biotechnology 2nd Year Syllabus

The second-year BTech Biotechnology syllabus semester wise focuses on subjects such as Fluid Mechanics, Bioorganic Chemistry, Molecular Biology, etc. Listed below is the BTech Biotechnology 3rd and 4th sem syllabus:

Semester III

Semester IV

Transforms and Partial Differential Equations

Probability and Statistics 

Basic Industrial Biotechnology

Fluid Mechanics and Heat Transfer Operations 

Bioorganic Chemistry

Molecular Biology

Applied Thermodynamics for Biotechnologists 

Enzyme Technology and Biotransformations

Stoichiometry

Bioprocess Principles

Cell Biology

Laboratory/ Practical Work

Laboratory/ Practical Work

-

Practical Topics for Second Year B.Tech Biotechnology Syllabus

Listed below are the BTech Biotechnology practical topics for 3rd and 4th semester:

  • Microbiology Laboratory
  • Cell Biology Laboratory
  • Chemical Engineering Laboratory for Biotechnologists 
  • Molecular Biology Laboratory

Read more: Scope of BTech Biotechnology in India

B.Tech Biotechnology 3rd Year Syllabus

The BTech in Biotechnology third-year syllabus covers subjects such as Bioinformatics, Protein Engineering, Chemical Reaction Engineering, etc. Listed below is the syllabus of B Tech Biotechnology 5th and 6th semester:

Semester V

Semester VI

Mass Transfer Operations

Bioinformatics

Bioprocess Engineering

Genetic Engineering 

Analytical Methods and Instrumentation

Applied Chemical Reaction Engineering

Protein Engineering

Animal Biotechnology / Systems Biology / Biological Spectroscopy 

Biophysics / Principles of Food Processing / Advanced Biochemistry 

Cancer Biology / Molecular Pathogenesis of Infectious Diseases / Biopharmaceutical Technology

Laboratory/ Practical Work

Metabolic Engineering / Structural Biology / Genomics and Proteomics 

-

Laboratory/ Practical Work

Practical Topics for Third Year B.Tech Biotechnology Syllabus

Listed below are the BTech Biotechnology practical topics for 5th and 6th semester:

  • Bioprocess Laboratory 
  • Analytical Methods and Instrumentation Laboratory
  • Genetic Engineering Laboratory

B.Tech Biotechnology 4th Year Syllabus

The B.Tech Biotechnology 4th year syllabus covers subjects such as Immunology, Quality Management, Genetics, etc. Listed below are the BTech Biotechnology 7th-semester and 8th-semester syllabi:

Semester VII

Semester VIII

Quality Control Management in Biotechnology 

Principles of Management & Entrepreneurial Development 

Downstream Processing

Project Work

Immunology 

-

Plant Biotechnology / Bioconjugate Technology and Applications / Genetics

-

Neurobiology and Cognitive Sciences / Tissue Engineering / Biosafety and Hazard Management 

-

Laboratory/ Practical Work

-

Practical Topics for Fourth Year BTech Biotechnology Syllabus

Listed below are the BTech Biotechnology practical topics for 7th and 8th semester:

  • Downstream Processing Laboratory
  • Immunology Laboratory

Read more: BSc Biotechnology vs BTech Biotechnology - Which is Better?

BTech Biotechnology Subjects - Core & Electives

The subjects in BTech Biotechnology are divided into core and elective courses. Students also prepare presentations and participate in discussions which helps them learn better as a part of the curriculum. Following are the year-wise subjects in B.Tech Biotechnology:

B.Tech Biotechnology Subjects 1st Year

The BTech Biotechnology subjects 1st year cover topics such as Engineering Mathematics, Biomolecules, Microbes, Metabolism Concepts, and more.

Listed below are the B.Tech Biotechnology subjects in 1st year and topics covered under them.

Subjects

Topics Covered

Subject Type

Communicative English

Vocabulory Development, Language Development, Grammar, Reading, Extended Writing

Core

Engineering Physics

Properties of Matter, Wave and Fiber Optics, Thermal Physics, Quantum Physics

Engineering Chemistry

Water and It’s Treatment, Surface Chemistry, Catalysis, Alloys, Phase Rule, Fuels & Combustion, Energy Sources, Storage Devices

Engineering Mathematics-I

Differential Calculus, Partial Differentiation, Integral Calculus, Multiple Integrals, Differential Equations

Problem Solving and Python Programming 

Algorithmic Problem Solving, Data, Expressions, Statements, Control Flow, Functions, Lists, Tuples, Dictionaries, Files, Modules, Packages

Engineering Graphics 

Plane Curves, Projection of Points Lines & Plane Surface, Projection of Solids, Isometric & Perspective Projections

Engineering Mathematics-II

Matrices, Vector Calculus, Analytic Functions, Complex Integration, Laplace Transform

Material Science

Preparation of Materials, Conducting Materials, Seminconducting Materials, Dielectric and Magnetic Materials

Civil and Mechanical Engineering

Structural, Construction, Geotechnical, Environmental, Transportation, Water Resources Engineering , Production, Automobile, Energy Engineering

Microbiology

Microbes, Microbial Nurtrition Growth & Metabolism, Control of Microorganisms, Industrial & Environmental Microbiology

Biochemistry

Biomolecules, Carbohydrates, Structure & Properties of Other Biomolecules, Metabolism Concepts, Carbohydrate Metabolism, Protein Transport

Environmental Studies

Environment, Ecosystem, Biodiversity, Environmental Pollution

Problem-Solving and Python Programming Laboratory

Write Test & Debug Python Program, Python Program with Conditionals & Loops, Structuring Python Programs, Compound Data

Laboratory/Practical

Physics and Chemistry Laboratory

Principles of Elasticity, Optics, Thermal Properties, Quantitative Chemical Analysis of Water Related Parameters

Engineering Mechanics Laboratory

Buildings, Plumbing Works, Carpentry Using Power Tools, Welding, Machining, Sheet Metal Work

Biochemistry Laboratory

Qualitative & Quantitative Estimation of Biomolecules, Laboratory Analysis of Biomolecules in Body Fluid

B.Tech Biotechnology Subjects 2nd Year

The BTech Biotechnology subjects 2nd year focuses on concepts such as Bioproducts, Cell Biology, Fermentation Processes, and more.

The second year B.Tech Biotechnology subjects and topics covered are listed below.

Subjects

Topics Covered

Subject Type

Transforms and Partial Differential Equations

Fourier Series, Applications of Partial Differential Equations, Fourier Transforms, Z-Transfroms and Difference Equations

Core

Basic Industrial Biotechnology

Industrial Bioprocess, Primary Metabolites, Secondary Metabolites, Enzymes, Bioproducts, Modern Biotechnology Products

Bioorganic Chemistry

Bonding & Stereochemistry, Substitution & Addition Reactions, Kinetics, Catalysis, Bioorganic Reactions

Applied Thermodynamics for Biotechnologists 

Thermodynamic Law, Properties of Fluids, Solution Thermodynamics, Phase Equilibria, Chemical Reaction Equilibria

Stoichiometry

Chemical Calculations, Ideal & Actual Gas Equations, Material Balance, Energy Balance, Chemical Reaction

Cell Biology

Cell Structure, Cell Division, Cancer, Transport Across Cell Membrane, Signal Transduction

Probability and Statistics 

Probability & Random Variables, 2D Random Variables, Testing of Hypotheis, Design of Experiments, Statistical Quality Control

Fluid Mechanics and Heat Transfer Operations 

Fluid Properties, Fluid Mechanica, Fluid Flow, Heat Transfer Conduction, Convection, Radiation, Equipments

Molecular Biology

Chemistry of Nucleic Acids, DNA Replication & Repair, Transcription

Enzyme Technology and Biotransformations

Kinetics of Enzyme Action, Enzyme Immobilization & Biosensors, Biotransformation

Bioprocess Principles

Fermentation Processes, Raw Materials & Media Design for Fermentation Process, Sterilization Kinetics

Microbiology Laboratory

Sterilization Techniques, Culture Media & Techniques, Microscopy, Staining Techniques, Antibiotic Sensitivity Assay

Laboratory/Practical

Cell Biology Laboratory

Sterile Techniques, Cell Propagation, Phase Contrast, Fluorescent Microscopy, Staining, Osmosis, Tonicity

Chemical Engineering Laboratory for Biotechnologists

Flow Measurement, Pressure Drop, Centrifuge Pump, Filtration

Molecular Biology Laboratory

Electrophoresis, Competent Cells Preparation, Transformation, Antibiotic Sensitivity Assay

B.Tech Biotechnology Subjects 3rd Year

The B.Tech Biotechnology 3rd year subjects focus on topics such as Bioreactors, Protein Structure Analysis, Spectroscopy, etc. The B.Tech Biotechnology subjects and topics covered are given in the table below.

Subjects

Topics Covered

Subject Type

Mass Transfer Operations

Diffusion & Mass Transfer, Gas Liquid Operations, Vapour Liquid Operations, Extraction Operations, Solid Fluid Operations

Core

Bioprocess Engineering

Bioreactors, Bioreactor Consideration in Enzyme Systems, Modelling & Simulation of Bioprocesses, Recombinant Cell Cultivation

Analytical Methods and Instrumentation

Spectrometry, Spectroscopy, Magnetic Resonance Spectroscopy & Mass Spectroscopy, Separation Methods, Electro Analysis & Surface Microscopy

Protein Engineering

Protein Architecture, Tertiary Structure, Structure-Function Relationship, Proteomics

Bioinformatics

Sequence Alignment, Phylogenetic Methods, Protein Structure Analysis, Perl Programming

Genetic Engineering 

Recombinant DNA Technology, DNA Libraries, Sequencing & Amplification of DNA, Organization and Structure of Genomes, Current Status of Genome Sequencing Projects

Applied Chemical Reaction Engineering

Scope of Chemical Kinetics, Chemical Reaction Engineering, IDeal Reactors, Non Ideal Reactors

Biophysics 

Molecular Structure of Biological Systems, Conformation of Nucleic Acids Protein, Cellular Permeability and Iin-Transport, Energetics & Dynamics of Biplogical Systems

Elective

Principles of Food Processing 

Food & Energy, Food Additives, Food Borne Diseases, Food Preservation

Advanced Biochemistry

Metabolism of Amino Acids, Protein Transport and Degradation, Biochemistry of Muscle Contraction, Vitamins & Coenzymes, Hormones

Animal Biotechnology 

Animal Cell Structure, Animal Diseases and Their Diagnosis, Micromanipulation of Embryo’s. Transgenic Animals

Systems Biology 

Kinetic Modeling, Flux Balance Analysis, Network Motifs and Models, Resources and SBML

Biological Spectroscopy

Nuclear Magnetic Resonance, Mass Spectrometry, X-ray Diffraction

Cancer Biology 

Carcinogenesis, Molecular Cell Biology of Cancer, Cancer Metastasis, Cancer Therapy

Molecular Pathogenesis of Infectious Diseases

Host-Defence Against Pathogens, Molecular Pathogenesis, Host-Pathogen Interactions

Biopharmaceutical Technology

Drug Action, Pharmacokinetics, Manufacture of Drugs Process & Applications, Drug Manufacture

Metabolic Engineering

Pathway Manipulation-Qualitative Treatment, Material Balances & Data Consistency, Metabolic Flux Analysis, Metabolic Control Analysis

Structural Biology 

Protein Structure, Protein Thermodynamics, Kinetics, Computational Structural Biology

Genomics and Proteomics 

Genome Mapping, Sequencing, Functional Genomics, Proteomics Technique, Protein Profiling

Bioprocess Laboratory 

Enzyme Characterization, Immobilization, Medium Optimization Methods

Laboratory/Practical

Analytical Methods and Instrumentation Laboratory

Absorption Spectroscopic Methods, Chromatography, Spectrometric, Microscopic Techniques

Genetic Engineering Laboratory 

Plasmid DNA, Restriction Digestion, Ligation, Transformation & Selection of Recombinant

B.Tech Biotechnology Subjects 4th Year

The final year BTech Biotechnology subjects cover topics such as Quality Management, Immune Systems, Genetics, and more. 

The B.Tech Biotechnology subjects 4th year are provided in the table below.

Subjects

Topics Covered

Subject Type

Quality Control Management in Biotechnology 

Quality Management, Pharmacopoeias, GMP, Indian Regulatory Agencies, Accreditation

Core

Downstream Processing

Physical Methods of Separation, Isolation of Products, Product Purification, Final Product Formulation

Immunology 

Immune System, Humoral & Cellular Immunity, Hypersensitivity, Applied Immunology

Principles of Management & Entrepreneurial Development 

Definition, Purpose, Organising, Human Resource Management

Plant Biotechnology

Genetic Material, Chloroplast, Mitochondria, Nitrogen Fixation, Agrobacterium, Viral Vectors

Elective

Bioconjugate Technology and Applications 

Functional Targets, Chemistry of Active Groups, Bioconjugate Reagents, Enzyme and Nucleic Acid Modification & Conjugation, Bioconjugate Applications

Genetics

Bacterial Genetics, Classical Genetics, Applied Genetics, Population Genetics, Genetic Diseases

Neurobiology and Cognitive Sciences 

Neuroanatomy, Neurophysiology, Neuropharmacology, Applied Neurobiology, Behaviour Science

Tissue Engineering 

Tissue Architecture, Biomaterials, Basic Biology of Stem Cells, Clinical Applications

Biosafety and Hazard Management

Quality Checks, Risk Analysis, Safety Audits, Hazardous Operations

Downstream Processing Laboratory

Centrifugation, Microfiltration, Ultra Filtration Separation, Cell Disruption Techniques

Laboratory/Practical

Immunology Laboratory 

Immunological / Clinical Tests, Immunodiffusion, Isolation

BTech Biotechnology Course Structure

The BTech Biotechnology course structure is a mix of theoretical knowledge and practical knowledge which includes projects, group discussions, research papers, and also internships. The BTech Biotechnology course structure includes:

  • Core and Elective Subjects
  • VIII Semesters
  • Projects
  • Research Papers
  • Surveys
  • Seminars
  • Practicals
  • Thesis Writing 

BTech Biotechnology Teaching Methodologies and Techniques

The teaching methodology for B.Tech Biotechnology involves a combination of classroom teaching along with teaching through real-world application of that knowledge through case study projects. 

This teaching methodology helps in building a comprehensive understanding of biotechnology concepts. Through this methodology, students can understand the world of genomics, artificial modelling, etc. Some teaching methodologies and techniques used by colleges are:

  • Discussions 
  • Field trips
  • Practical Learnings
  • Problem-based 
  • Projects
  • E-learning
  • Co-curricular activities 

BTech Biotechnology Projects

Biotechnology combines biology with technology and offers a vast opportunity for doing projects during the final semester. BTech Biotechnology projects help boost students' confidence by applying the practical use of their learnings and help them make better leaders and decision-makers. 

Listed below are some popular BTech Biotechnology project topics:

  • Production Of Ethanol Using Molasses And Its Pollutant Treatment
  • Scattering Parameters Of Circulator Biotechnology
  • Various Methods Of Evapotranspiration
  • Renewable Energy Technology Management Promoting Village

BTech Biotechnology Reference Books

The B.Tech Biotechnology books cover foundational concepts and theories, methodologies, practical applications, and laboratory experiments for students to refer to. 

The year-wise B.Tech Biotechnology books followed in most colleges is provided in the sections below.

B.Tech Biotechnology Books First Year

The first year B.Tech Biotechnology books cover foundational concepts and topics such as Microbiology, Biochemistry, Basic Engineering, and more.. 

The 1st year B.Tech Biotechnology books are provided in the table below.

Books

Authors 

Topics Covered

Foundations in Microbiology

Talaron K, Talaron A, Casita, Pelczar and Reid

Microbial Cell Structure, Microbial Growth & Control, Metabolism

Advanced Engineering Mathematics

Erwin Kreyszig

Differential Equations, Vector Calculus, Optimization Techniques

Biochemistry

Satyanarayana, U. and U. Chakerapani

Enzymology, Bioenergetics, Clinical Biochemistry

Outlines of Biochemistry

E.E. Conn

Cell Structure, Amino Acids, Proteins

B.Tech Biotechnology Books Second Year

The B.Tech Biotechnology second year books cover topics such as Cell Biology, Enzyme Technology, Bioprocess Principles, etc. 

Listed below are the 2nd year B.Tech Biotechnology books for the second year.

Books

Authors 

Topics Covered

Stoichiometry

Bhatt B.I & SB Thakore

Chemical Equations, Chemical Reactors,  Energy Balanaces

Basic principles & Calculations in Chemical Engineering

Himmelblau D.M

Process Variables, Energy Balances, Process Simulation

Chemical and Engineering Thermodynamics

Sandler S.I.

Laws of Thermodynamics, Phase Equiliibria, Biochemical Engineeiring

A Textbook on Biotechnology

Kumar, H.D

Cell Biology, Genetics, Enzyme Technology

B.Tech Biotechnology Books Third Year

The third-year B.Tech Biotechnology books deal with advanced concepts of Biotechnology such as Bioprocess Engineering, Protein Technology, Bioinformatics, etc. 

The B.Tech Biotechnology third year books are listed below.

Books

Authors 

Topics Covered

Cell Biology: Essential Techniques

Rickwood, D. and J.R. Harris

Cell Culture Technique, Microscopy Techniques, Cell Fractionation

Heat & Mass Transfer 

P. K. Nag

Conduction Heat Transfer, Convection Heat Transfer, Heat Exchangers

Molecular Biology

David Friefelder

Nucleic Acids, DNA Replication, RNA Transcription

Biotransformations in Organic Chemistry

K. Faber

Enzyme Catalysis, Oxidation, Hydrolysis

B.Tech Biotechnology Books Fourth Year

The fourth year B.Tech Biotechnology books cover important topics such as Downstream Processing,Quality Control Management, Immunology, etc.

 Listed below are some of the B.Tech Biotechnology books used in the fourth year.

Books

Authors 

Topics Covered

Total Quality Management

Suganthi.L and Anand Samuel

Principles, Tools & Techniques, Statistical Process Control

Immunology

Ashim K. Chakravarthy

Immune System, Antigens, Antibodies, Effector Mechanisms

Biophysical Chemistry

Cantror, Charles R. and Paul R. Schimmel

Kinetics, Quantum Mechanics, Spectroscopic

Proteins: Structure and Molecular Properties

T.E. Creighton

Protein Dynamics, Protein Function, Protein-Ligand Interactions

BTech Biotechnology Fee Structure

FAQs

Is there maths in BTech Biotechnology?

Yes, the BTech Biotechnology syllabus includes Mathematics in Semester 1-4 and it may vary based on the institution.

Can I join BTech Biotechnology without maths?

No, most universities make it compulsory for the candidates to have a maths background to be eligible for the admission into BTech Biotechnology course.

How many subjects are there in Biotechnology?

Btech Biotechnology syllabus is divided into 8 semesters with each one having 5-6 subjects on average. The BTech Biotechnology subjects include Mathematics, biophysics & instrumentation, Cell Structure, Cell Biology, Biochemistry, etc.

Is BTech Biotechnology hard?

No, the BTech Biotechnology course focuses mainly on the concepts of Biology and Biotechnology and for candidates with PCM or PCB stream in class 10+2, the course curriculum will be very interesting and easier.

Is coding taught in BTech Biotechnology?

The BTech Biotechnology students will be taught basic computer skills and programming languages as a part of the syllabus.

Is Python required for Biotechnology?

Yes, it is recommended that candidates have basic knowledge and understanding about Python and Javascript to thrive in the biotech industry

What are the core B.Tech subjects semester wise for the 3rd year?

The core topics for the 1st semester include Mass Transfer Operations, Bioprocess Engineering, Analytical Methods & Instrumentation, and Protein Engineering. The 2nd-semester core topics include Bioinformatics, Genetic Engineering, and Applied Chemical Reaction Engineering.

Is there a focus on skill development in Btech biotechnology syllabus?

Yes, the syllabus emphasizes skill development through practical labs, projects, internships, and research. Students gain skills in bioprocess design, genetic engineering, bioinformatics, and more.

Are there any elective subjects in the B.Tech Biotechnology syllabus?

Yes, the B.Tech Biotechnology syllabus includes elective subjects such as Cell Biology, Stoichiometry, Molecular Biology, Cell Biology, and more.

What kind of practical work is involved in BTech Biotech syllabus?

The BTech Biotech syllabus involves extensive practical work in labs focused on Microbiology, Cell Biology, Biochemistry, etc where students gain skills in cell structure, DNA manipulation, enzymes assays, and more.

How is the B.Tech Biotechnology syllabus assessed?

The B.Tech Biotechnology syllabus is assessed in the form of written exams, assignments, projects, and viva voce to evaluate the students of their understanding.

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